SMALL-SAMPLE LOGISTIC REGRESSION WITH PENALIZED LIKELIHOOD AND PRINCIPAL COMPONENT ANALYSIS
DOI:
https://doi.org/10.69980/jpc4eb82Keywords:
Principal component analysis, Firth logistic regression, penalized likelihood, small-sample modelling, binary classificationAbstract
This study examined the applicability of the principal component analysis (PCA) and Firth penalized logistic regression (FPLR) approach to modelling binary outcomes with small samples. An open-access dataset of 23 older adults and their demographic, health-related, and eight predictor variables from questionnaires was used to complete a secondary quantitative analysis. The binary outcome consisted of 11 observations in class 0 and 12 observations in class 1. The eight variables from the questionnaire were standardised and then subjected to PCA, the Kaiser-Meyer-Olkin statistic was used to assess sampling adequacy. PCs 1 and 2 were kept for further Firth logistic regression. The PCA analysis revealed that PC1 and PC2 accounted for 47.71% and 19.46% of the variance, respectively, with a total of 67.18% variance explained. In the penalized regression model, PC1 was found to be associated with the binary outcome (OR = 16.68, p < 0.001), while PC2 was not (OR = 0.77, p = 0.792). For the model, in-sample accuracy, sensitivity, specificity, precision and F1-score were all 100% while the AUC was 1.000. The results are preliminary due to the very limited sample size and lack of external validation, however. In conclusion, the PCA–Firth framework was a parsimonious exploratory framework for small-sample binary classification problems in which predictors are correlated.
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